Blogger Widgets Orang Kuantan: Protein Data Bank (PDB)

Wednesday, 26 September 2012

Protein Data Bank (PDB)



Alhamdullilah, praise to be upon HIM, The Most Gracious and Merciful Lord. Today, we are  fortunate to learn new things that practically can be apply in our daily life. Our new lessons for Computer in Science is related with Protein Data Bank (PDB). Basically, we apply the concept in our learning progress. As a future biotechs, surelt this lessons are hepling us a lot.

      First and foremost, we will like to share what is Protein Data Bank (PDB) is all about. According to the page distributor RCSB, PDB is a repository for 3D structural data of large biological molecules, such as proteins and nucleic acids, This data is typically obtained by X-Ray crystallography or NMR spectroscopy and submitted by biologists and biochemists from all around the world, which are freely accessible on the Internet via the websites of its member organizations.

     From what we have learnt, our group was assigned to download some molecule from Protein Data Bank, HtrA, CLP B, CLP P, Trypsin and Lex A. The graphics is downloaded and edited by using Raswin, a freeware program developed to view and edit PDB files from the Internet.

What is Raswin
Raswin is a computer program written for molecular graphics visualization intended and used primarily for the depiction and exploration of biological macromolecule structures, such as those found in the Protein Data Bank. It was originally developed by Roger Sayle in the early 90s.Historically, it was an important tool for molecular biologists since the extremely optimized program allowed the software to run on (then) modestly powerful personal computers. Before RasMol, visualization software ran on graphics workstations that, due to their expense, were less accessible to scholars. RasMol has become an important educational tool as well as continuing to be an important tool for research in structural biology.

Here is our outcomes,

Name
Picture
Classification




Trypsin




Shape: Ball and stick
Colour: CPK
Movement: Pick cord and rotate bond 






Lex A







Shape: Strands
Colour: Chain
Movements: Pick distance and rotate mol 







 HTR A






Shape: Space Fill
Colour: Structure
Movements: Pick monitor and pick angle 






CLP P 

  




 Shape: Ribbon
Colour: Structure
Movements: Pick bond and rotate all







CLP B

  




Shape: Cartoon
Colour: Temperature
Movements: Coord and ident




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